The ADMA/DDAH Pathway Regulates VEGF-Mediated Angiogenesis
نویسندگان
چکیده
منابع مشابه
The ADMA/DDAH pathway regulates VEGF-mediated angiogenesis.
OBJECTIVE Asymmetrical dimethylarginine (ADMA) is a nitric oxide synthase (NOS) inhibitor and cardiovascular risk factor associated with angiogenic disorders. Enzymes metabolising ADMA, dimethylarginine dimethylaminohydrolases (DDAH) promote angiogenesis, but the mechanisms are not clear. We hypothesized that ADMA/DDAH modifies endothelial responses to vascular endothelial growth factor (VEGF) ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2009
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.109.194035